DNA repair inhibiting oligonucleotide

{
  "id": "MLC-T-ONC-013103",
  "term": "DNA repair inhibiting oligonucleotide",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of cell-permeant, short double-stranded DNA fragment that mimics double-strand breaks and linked to a cholesterol molecule, with potential antineoplastic activity. Upon administration of DNA repair inhibiting oligonucleotide, the cholesterol moiety enables tumoral and nuclear uptake of the DNA, and mimics DNA double-strand breaks (DSBs) inside the tumor cells. This triggers false DNA break signals, binding to and activating DNA repair proteins including both poly (ADP-ribose) polymerase (PARP) and DNA-dependent protein kinase (DNA-PK). This prevents the recruitment of these repair proteins at the actual damage site and inhibits various DNA DSB repair pathways including homologous recombination (HR) and non-homologous end joining (NHEJ). This promotes genetic instability and enhances the accumulation of single and double strand DNA breaks, ultimately leading to apoptosis.",
  "synonyms": [
    "DNA repair inhibiting oligonucleotide AsiDNA",
    "DSBs mimic",
    "oligonucleotide-mimicking double-stranded DNA breaks"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/dna-repair-inhibiting-oligonucleotide/"
}