DNAJB1-PRKACA fusion kinase peptide vaccine

{
  "id": "MLC-T-ONC-013107",
  "term": "DNAJB1-PRKACA fusion kinase peptide vaccine",
  "field": "Oncology and biomedicine",
  "definition": "A cancer peptide vaccine composed of a fusion peptide derived from the fusion protein DnaJ homolog subfamily B member 1-cAMP-dependent protein kinase catalytic subunit alpha fusion protein A (DNAJB1-PRKACA) that is encoded by the DNAJB1/PRKACA fusion gene, with potential immunomodulating and antineoplastic activities. Upon administration, the DNAJB1-PRKACA fusion kinase peptide vaccine may induce CD8 T cell- and CD4 T cell-mediated immune response against tumor cells expressing the DNAJB1-PRKACA fusion protein, which may result in the inhibition of proliferation in these tumor cells. The DNAJB1-PRKACA fusion protein is expressed in all fibrolamellar carcinoma (FLC) tumors and plays a key role in FLC tumorigenesis.",
  "synonyms": [
    "DNAJB1-PRKACA fusion peptide vaccine",
    "DNAJB1-PRKACA peptide vaccine",
    "fibrolamellar hepatocellular cancer peptide vaccine",
    "FLC peptide vaccine"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/dnajb1-prkaca-fusion-kinase-peptide-vaccine/"
}