doxycycline hyclate matrix formulation

{
  "id": "MLC-T-ONC-013163",
  "term": "doxycycline hyclate matrix formulation",
  "field": "Oncology and biomedicine",
  "definition": "An extended release (ER) formulation composed of the hyclate salt form of doxycycline, a synthetic, broad-spectrum tetracycline antibiotic, in a biodegradable, polymer-lipid encapsulation matrix (PLEX), with antimicrobial activity. Following reconstitution and administration in the surgical wound/incision, doxycycline is released from the matrix over an extended period of time. Upon release, doxycycline reversibly binds to the bacterial 30S ribosomal subunit, and blocks the binding of aminoacyl-tRNA to the mRNA-ribosome complex. This leads to an inhibition of bacterial protein synthesis. This may prevent surgical site infections.",
  "synonyms": [
    "doxycycline hyclate matrix extended-release formulation",
    "doxycycline polymer-lipid encapsulation matrix formulation"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/doxycycline-hyclate-matrix-formulation/"
}