Dulanermin

{
  "id": "MLC-T-ONC-013184",
  "term": "Dulanermin",
  "field": "Oncology and biomedicine",
  "definition": "A recombinant human soluble protein corresponding to amino acids 114-281 of the Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand (RhApo2L/TRAIL) with potential antineoplastic activity. Dulanermin binds to and activates TRAIL receptors 1 and 2 (TRAIL-R1/R2), which may activate caspases and induce p53-independent apoptosis in TRAIL-R1/R2-expressing tumor cells. The pro-apoptotic cell surface receptors TRAIL-R1 and -R2, also known as DR4 (death receptor 4) and DR5 (death receptor 5), are members of the TNF receptor family and are overexpressed by a variety of cancer cell types.",
  "abbreviation": "RhApo2L/TRAIL",
  "synonyms": [
    "recombinant TNF-related apoptosis-inducing ligand",
    "recombinant human Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/dulanermin/"
}