Elliptinium acetate

{
  "id": "MLC-T-ONC-013309",
  "term": "Elliptinium acetate",
  "field": "Oncology and biomedicine",
  "definition": "Acetate salt of elliptinium, a derivative of the alkaloid ellipticine isolated from species of the plant family Apocynaceae, including Bleekeria vitensis, a plant with anti-cancer properties. As a topoisomerase II inhibitor and intercalating agent, elliptinium stabilizes the cleavable complex of topoisomerase II and induces DNA breakages, thereby inhibiting DNA replication and RNA and protein synthesis.",
  "abbreviation": "NMHE",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/elliptinium-acetate/"
}