emtricitabine

{
  "id": "MLC-T-ONC-013327",
  "term": "emtricitabine",
  "field": "Oncology and biomedicine",
  "definition": "A synthetic fluoro derivative of thiacytidine with potent antiviral activity. Emtricitabine is phosphorylated to form emtricitabine 5'-triphosphate within the cell. This metabolite inhibits the activity of human immunodeficiency virus (HIV) reverse transcriptase both by competing with the natural substrate deoxycytidine 5'-triphosphate and by incorporation into viral DNA causing a termination of DNA chain elongation (due to the lack of the essential 3'-OH group).",
  "synonyms": [
    "FTC",
    "coviracil"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/emtricitabine/"
}