stavudine

{
  "id": "MLC-T-ONC-008285",
  "term": "stavudine",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A drug that belongs to the family of drugs called nucleoside analogs. It is used to treat infection caused by viruses.",
    "A synthetic nucleoside, analog of didehydro-3-deoxythymidine with potent antiretroviral activity. In vivo, stavudine is phosphorylated by cellular kinases to the active metabolite stavudine triphosphate; this metabolite inhibits the activity of HIV reverse transcriptase both by competing with the natural substrate deoxythymidine triphosphate and by incorporation into viral DNA causing a termination of DNA chain elongation (due to the lack the essential 3'-OH group)."
  ],
  "abbreviation": "d4T",
  "synonyms": [
    "didehydrodeoxythymidine",
    "dideoxydidehydrothymidine"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/stavudine/"
}