acyclovir

{
  "id": "MLC-T-ONC-000222",
  "term": "acyclovir",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A substance used to prevent or treat cytomegalovirus and herpes simplex infections that may occur when the body is immunosuppressed. It belongs to the family of drugs called antivirals.",
    "A synthetic analog of the purine nucleoside, guanosine, with potent antiviral activity against herpes simplex viruses type 1 and 2, varicella-zoster virus and other viruses of the herpesvirus family. After conversion in vivo to the active metabolite acyclovir triphosphate by viral thymidine kinase, acyclovir competitively inhibits viral DNA polymerase by incorporating into the growing viral DNA chain and terminating further polymerization."
  ],
  "abbreviation": "ACV",
  "synonyms": [
    "aciclovir",
    "acycloguanosine"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/acyclovir/"
}