enfortumab vedotin-ejfv

{
  "id": "MLC-T-ONC-013339",
  "term": "enfortumab vedotin-ejfv",
  "field": "Oncology and biomedicine",
  "definition": "An antibody drug conjugate (ADC) containing a human monoclonal antibody AGS-22 targeting the cell adhesion molecule nectin-4 and conjugated to the cytotoxic agent monomethyl auristatin E (MMAE), via a proprietary enzyme-cleavable linker (AGS-22CE), with potential antineoplastic activity. The monoclonal antibody moiety of enfortumab vedotin-ejfv electively binds to nectin-4. After internalization and proteolytic cleavage, MMAE binds to tubulin and inhibits its polymerization, which results in G2/M phase arrest and induces apoptosis in nectin-4 overexpressing tumor cells. Nectin-4, a tumor associated antigen belonging to the nectin family, is overexpressed in a variety of cancers, including breast, bladder, lung and pancreatic cancer.",
  "synonyms": [
    "enfortumab vedotin",
    "anti-nectin 4 ADC ASG-22CE",
    "anti-nectin-4 monoclonal antibody-drug conjugate AGS-22M6E"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/enfortumab-vedotin-ejfv/"
}