anti-nectin-4 antibody-drug conjugate ADRX-0706

{
  "id": "MLC-T-ONC-010916",
  "term": "anti-nectin-4 antibody-drug conjugate ADRX-0706",
  "field": "Oncology and biomedicine",
  "definition": "An antibody-drug conjugate (ADC) composed of a monoclonal antibody directed against the cell surface adhesion molecule and tumor-associated antigen (TAA) nectin-4 (PVRL4) that is conjugated to the tubulin inhibitor and cytotoxic agent AP052, with potential antineoplastic activity. Upon administration of the anti-nectin-4 ADC ADRX-0706, the anti-nectin-4 antibody targets and binds to nectin-4 expressed on tumor cells. Upon binding and internalization, AP052 targets and binds to tubulin, and inhibits its polymerization. This results in G2/M phase arrest and induces apoptosis in nectin-4-expressing tumor cells. Nectin-4, a TAA belonging to the nectin family, is overexpressed in a variety of cancers, but has a restricted distribution in normal tissue. It is associated with poor disease prognosis. ADRX-0706 has a drug-antibody ratio (DAR) of eight.",
  "synonyms": [
    "ADC ADRX-0706",
    "anti-nectin-4 ADC ADRX-0706",
    "anti-nectin-4/AP052 antibody-drug conjugate ADRX-0706"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-nectin-4-antibody-drug-conjugate-adrx-0706/"
}