Ensartinib hydrochloride

{
  "id": "MLC-T-ONC-002854",
  "term": "Ensartinib hydrochloride",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A drug used to treat adults with non-small cell lung cancer that is ALK positive, has spread, and has not been treated with an ALK inhibitor. It is also being studied in the treatment of other types of cancer. Ensartinib hydrochloride blocks certain proteins made by the ALK gene, which may help keep cancer cells from growing. It is a type of kinase inhibitor. Also called Ensacove.",
    "The hydrochloride salt form of ensartinib, an orally available small molecule inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK), with potential antineoplastic activity. Upon oral administration, ensartinib binds to and inhibits ALK kinase, ALK fusion proteins and ALK point mutation variants. Inhibition of ALK leads to the disruption of ALK-mediated signaling and eventually inhibits tumor cell growth in ALK-expressing tumor cells. In addition, ensartinib inhibits various other kinases, including the receptor tyrosine kinase c-Met (hepatocyte growth factor receptor; HGFR; MET) and the receptor tyrosine kinase C-ros oncogene 1 (ROS1). ALK belongs to the insulin receptor superfamily and plays an important role in nervous system development. ALK is not expressed in healthy adult human tissue but ALK dysregulation and gene rearrangements are associated with a series of tumors; ALK mutations are associated with acquired resistance to small molecule tyrosine kinase inhibitors."
  ],
  "synonyms": [
    "Ensacove"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/ensartinib-hydrochloride/"
}