Ensituximab

{
  "id": "MLC-T-ONC-013363",
  "term": "Ensituximab",
  "field": "Oncology and biomedicine",
  "definition": "A chimeric monoclonal antibody against human colorectal and pancreatic carcinoma-associated antigens (CPAAs) with potential immunomodulating and anti-tumor activities. Ensituximab binds to CPAAs, which may activate the immune system to exert a cytotoxic T-lymphocyte (CTL) response and an antibody-dependent cellular cytotoxicity (ADCC) response against CPAA-expressing tumor cells. CPAAs, cell surface proteins, are upregulated on colon and pancreatic tumor cells. Ensituximab contains the variable region of the heavy and light chain of murine NPC-1 and linked in-frame to constant regions of a human IgG1 isotype.",
  "synonyms": [
    "anti-pancreatic and colorectal carcinoma-associated antigen monoclonal antibody NPC-1C",
    "anti-CPAA monoclonal antibody NPC-1C"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/ensituximab/"
}