anti-CLDN18.2 heavy chain antibody Fc fusion protein DR30303

{
  "id": "MLC-T-ONC-010508",
  "term": "anti-CLDN18.2 heavy chain antibody Fc fusion protein DR30303",
  "field": "Oncology and biomedicine",
  "definition": "A fusion protein composed of a recombinant humanized anti-Claudin18.2 (CLDN18.2; A2 isoform of claudin-18) heavy chain antibody (VHH) fused to an engineered immunoglobulin gamma-1 (IgG1) Fc fragment, with potential immunostimulating and antineoplastic activities. Upon administration, anti-CLDN18.2 heavy chain antibody Fc fusion protein DR30303 specifically targets, binds to and inhibits CLDN18.2 expressed on tumor cells. The binding induces antibody-dependent cellular cytotoxicity (ADCC) and may kill CLDN18.2-expressing tumor cells and inhibit tumor cell proliferation. CLDN18.2, a tight junction protein and stomach-specific isoform of claudin-18, is overexpressed on a variety of tumor cells. Its expression in healthy tissues is strictly confined to short-lived differentiated epithelial cells of the gastric mucosa.",
  "synonyms": [
    "anti-CLDN18.2 VHH-Fc DR30303",
    "VHH-Fc DR30303",
    "fusion protein DR30303"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-cldn18-2-heavy-chain-antibody-fc-fusion-protein-dr30303/"
}