anti-CLDN18.2/anti-CD3 bispecific antibody ASP2138

{
  "id": "MLC-T-ONC-010511",
  "term": "anti-CLDN18.2/anti-CD3 bispecific antibody ASP2138",
  "field": "Oncology and biomedicine",
  "definition": "A bispecific antibody directed against the tumor-associated antigen (TAA) Claudin18.2 (CLDN18.2; A2 isoform of claudin-18) and the human T-cell surface antigen CD3, with potential immunostimulatory and antineoplastic activities. Upon administration, anti-CLDN18.2/anti-CD3 bispecific antibody ASP2138 simultaneously binds to both CLDN18.2-expressing tumor cells and CD3-expressing T cells, thereby crosslinking CLDN18.2-expressing tumor cells and cytotoxic T lymphocytes (CTLs). This results in the activation and proliferation of T cells and causes CTL-mediated cell lysis of CLDN18.2-expressing tumor cells. CLDN18.2, a tight junction protein and stomach-specific isoform of claudin-18, is expressed on a variety of tumor cells. Its expression in healthy tissues is strictly confined to short-lived differentiated epithelial cells of the gastric mucosa.",
  "synonyms": [
    "anti-Claudin18.2/anti-CD3 bispecific antibody ASP2138",
    "anti-Claudin18.2/CD3 bispecific antibody ASP2138",
    "Claudin18.2 x CD3 bispecific antibody ASP2138"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-cldn18-2-anti-cd3-bispecific-antibody-asp2138/"
}