anti-CD3/anti-Claudin 18.2 bispecific antibody IBI389

{
  "id": "MLC-T-ONC-010377",
  "term": "anti-CD3/anti-Claudin 18.2 bispecific antibody IBI389",
  "field": "Oncology and biomedicine",
  "definition": "A bispecific antibody directed against the tumor-associated antigen (TAA) Claudin18.2 (CLDN18.2; A2 isoform of claudin-18) and the human T-cell surface antigen CD3, with potential immunostimulatory and antineoplastic activities. Upon administration, anti-CD3/anti-CLDN18.2 bispecific antibody IBI389 simultaneously binds to both CD3-expressing T cells and CLDN18.2-expressing cancer cells, thereby crosslinking CLDN18.2-expressing tumor cells and cytotoxic T lymphocytes (CTLs). This results in the activation and proliferation of T cells and causes CTL-mediated cell lysis of CLDN18.2-expressing tumor cells. CLDN18.2, a tight junction protein and stomach-specific isoform of claudin-18, is expressed on a variety of tumor cells. Its expression in healthy tissues is strictly confined to short-lived differentiated epithelial cells of the gastric mucosa.",
  "synonyms": [
    "anti-CD3/anti-CLDN18.2 bispecific antibody IBI389",
    "anti-Claudin18.2/CD3 bispecific antibody IBI389",
    "anti-CLDN18.2/anti-CD3 bispecific antibody IBI389",
    "CLDN18.2 x CD3 bispecific antibody IBI389"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-cd3-anti-claudin-18-2-bispecific-antibody-ibi389/"
}