EP4 antagonist ONO-4578

{
  "id": "MLC-T-ONC-013378",
  "term": "EP4 antagonist ONO-4578",
  "field": "Oncology and biomedicine",
  "definition": "An orally bioavailable antagonist of the prostaglandin E2 receptor subtype 4 (PTGER4; EP4), with potential analgesic, immunomodulating and antineoplastic activities. Upon administration, the EP4 antagonist ONO-4578 selectively targets and binds to EP4, inhibiting the binding of the immunosuppressive prostaglandin E2 (PGE2) to EP4. This prevents the activation of EP4 and inhibits PGE2-EP4-mediated signaling, thereby inhibiting proliferation of tumor cells in which the PGE2-EP4 signaling pathway is over-activated. In addition, EP4 inhibition prevents the activity of tumor-associated myeloid cells (TAMCs) in the tumor microenvironment (TME) by inhibiting interleukin-23 (IL-23) production and the IL-23-mediated expansion of Th17 cells. EP4, a prostanoid receptor, is a G protein-coupled receptor that is expressed in certain types of cancers; it promotes tumor cell proliferation and invasion.",
  "synonyms": [
    "prostaglandin E2 receptor antagonist ONO-4578",
    "PGE2 receptor antagonist ONO-4578",
    "selective PGE2 receptor 4 antagonist ONO-4578"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/ep4-antagonist-ono-4578/"
}