EphA2-targeting DOPC-encapsulated siRNA

{
  "id": "MLC-T-ONC-013383",
  "term": "EphA2-targeting DOPC-encapsulated siRNA",
  "field": "Oncology and biomedicine",
  "definition": "A liposomal formulation consisting of short-interfering RNAs (siRNAs) directed against ephrin type-A receptor 2 (EphA2) and encapsulated into 1,2-dioleoyl-sn-glycero-3-phosphatidylcholine (DOPC) neutral liposomes, with potential antineoplastic activity. Upon internalization, EphA2-targeting DOPC-encapsulated siRNA can hybridize to EphA2 DNA and mRNA, thereby interfering with both the transcription and translation of EphA2, and thus inhibiting tumor cell growth. The cell-surface receptor EphA2, a member of the ephrin family of receptor tyrosine kinases (RTKs) involved in mammalian development, is overexpressed by a variety of different cancer cell types and plays an important role in tumor growth.",
  "synonyms": [
    "siRNA-EphA2-DOPC"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/epha2-targeting-dopc-encapsulated-sirna/"
}