Anti-androgen siRNA SXL01

{
  "id": "MLC-T-ONC-010122",
  "term": "Anti-androgen siRNA SXL01",
  "field": "Oncology and biomedicine",
  "definition": "A small-interfering RNA (siRNA) directed against androgen receptor (AR), with potential antineoplastic activity. Upon administration of anti-AR siRNA SXL01, the siRNAs bind to AR mRNAs, which may result in the inhibition of translation of the AR protein. By preventing AR expression, AR-mediated signaling is decreased, which leads to growth inhibition for AR-expressing tumor cells. AR, overexpressed in a variety of cancers, is involved in cellular proliferation and survival.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-androgen-sirna-sxl01/"
}