androgen receptor antagonist ONC1-0013B

{
  "id": "MLC-T-ONC-010065",
  "term": "androgen receptor antagonist ONC1-0013B",
  "field": "Oncology and biomedicine",
  "definition": "An orally bioavailable antagonist of the androgen receptor (AR), with potential antineoplastic activity. Upon oral administration, AR antagonist ONC1-13B specifically binds to AR, prevents AR activation, downregulates AR expression and prevents AR-mediated signaling. This inhibits cell growth in AR-overexpressing tumor cells. AR is overexpressed in prostate cancers and is involved in proliferation, survival and chemoresistance of tumor cells.",
  "synonyms": [
    "AR antagonist ONC1-0013B"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/androgen-receptor-antagonist-onc1-0013b/"
}