Androgen receptor antagonist BAY 1161116

{
  "id": "MLC-T-ONC-010064",
  "term": "Androgen receptor antagonist BAY 1161116",
  "field": "Oncology and biomedicine",
  "definition": "An orally bioavailable antagonist of the androgen receptor (AR), with potential antineoplastic activity. Upon oral administration, AR antagonist BAY 1161116 specifically binds to AR, inhibits AR activation, and prevents AR-mediated signaling. This inhibits cell growth in AR-overexpressing tumor cells. AR is overexpressed in prostate cancers and is involved in proliferation, survival and chemoresistance of tumor cells.",
  "synonyms": [
    "AR antagonist BAY 1161116"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/androgen-receptor-antagonist-bay-1161116/"
}