Epirubicin hydrochloride

{
  "id": "MLC-T-ONC-002906",
  "term": "Epirubicin hydrochloride",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A drug used with other drugs to treat breast cancer that was removed by surgery and has spread to the lymph nodes under the arm. It is also being studied in the treatment of other types of cancer. Epirubicin hydrochloride blocks a certain enzyme needed for cell division and DNA repair and may kill cancer cells. It is a type of anthracycline antibiotic and a type of topoisomerase inhibitor. Epirubicin is the active ingredient of epirubicin hydrochloride. Also called Ellence.",
    "The hydrochloride salt of the 4'-epi-isomer of the anthracycline antineoplastic antibiotic doxorubicin. Epirubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. This agent also produces toxic free-radical intermediates and interacts with cell membrane lipids causing lipid peroxidation."
  ],
  "synonyms": [
    "Ellence"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/epirubicin-hydrochloride/"
}