eribulin mesylate

{
  "id": "MLC-T-ONC-002951",
  "term": "eribulin mesylate",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A drug used to treat certain types of breast cancer and liposarcoma (a type of soft tissue sarcoma) that have already been treated with other anticancer drugs. It is also being studied in the treatment of other types of cancer. Eribulin mesylate blocks cell growth by stopping cell division and may kill cancer cells. It is a type of antimicrotubule agent. Also called E7389 and Halaven.",
    "The mesylate salt of a synthetic analogue of halichondrin B, a substance derived from a marine sponge (Lissodendoryx sp.) with antineoplastic activity. Eribulin binds to the vinca domain of tubulin and inhibits the polymerization of tubulin and the assembly of microtubules, resulting in inhibition of mitotic spindle assembly, induction of cell cycle arrest at G2/M phase, and, potentially, tumor regression."
  ],
  "synonyms": [
    "E7389",
    "Halaven",
    "halichondrin B analog"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/eribulin-mesylate/"
}