Halichondrin analogue E7130

{
  "id": "MLC-T-ONC-014057",
  "term": "Halichondrin analogue E7130",
  "field": "Oncology and biomedicine",
  "definition": "A halichondrin analogue derived from a marine sponge with potential antineoplastic activity. Upon intravenous infusion, halichondrin analogue E7130 may bind to the vinca domain of tubulin and inhibit the polymerization of tubulin and the assembly of microtubules, thereby inhibiting mitotic spindle assembly and inducing cell cycle arrest at the G2/M phase.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/halichondrin-analogue-e7130/"
}