hemiasterlin analogue E7974

{
  "id": "MLC-T-ONC-014077",
  "term": "hemiasterlin analogue E7974",
  "field": "Oncology and biomedicine",
  "definition": "An analogue of the sponge-derived anti-microtubule tripeptide hemiasterlin with antimitotic and potential antineoplastic activities. Hemiasterlin analogue E7974 binds to the Vinca domain on tubulin, resulting in inhibition of tubulin polymerization and microtubule assembly; depolymerization of exsiting microtubules; inhibition of mitosis; and inhibition of cellular proliferation. This agent may have more affinity for the beta-3 tubulin isotype.",
  "synonyms": [
    "hemiasterlin analog E7974"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/hemiasterlin-analogue-e7974/"
}