filgrastim

{
  "id": "MLC-T-ONC-003210",
  "term": "filgrastim",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A drug used under the brand names Neupogen, Zarxio, and Nivestym to treat neutropenia (a lower-than-normal number of white blood cells), prevent infection, and prepare the blood for the collection of certain types of blood cells, and under the brand name Granix to treat neutropenia. Filgrastim is used in patients who have certain cancers and neutropenia caused by some types of chemotherapy and in patients who have severe chronic neutropenia that is not caused by cancer treatment. It is also used before an autologous stem cell transplant. Filgrastim helps the bone marrow make more white blood cells. It is a type of colony-stimulating factor. Also called G-CSF and granulocyte colony-stimulating factor.",
    "A recombinant, non-glycosylated cytokine which is chemically identical to or similar to the endogenous cytokine human granulocyte colony-stimulating factor (G-CSF) isoform B, with immunomodulating activity. Filgrastim binds to and activates G-CSF receptors with the same biological activity and stability as the endogenous cytokine, thereby controlling the production, differentiation, and function of neutrophilic granulocyte progenitors."
  ],
  "abbreviation": "rG-CSF",
  "synonyms": [
    "G-CSF",
    "granulocyte colony-stimulating factor",
    "filgrastim-ayow",
    "filgrastim-aafi",
    "Tbo-filgrastim",
    "recombinant methionyl human granulocyte colony stimulating factor",
    "filgrastim XM02",
    "filgrastim-sndz"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/filgrastim/"
}