Fluocinonide cream

{
  "id": "MLC-T-ONC-013646",
  "term": "Fluocinonide cream",
  "field": "Oncology and biomedicine",
  "definition": "A topical cream containing the synthetic glucocorticoid fluocinonide, with anti-inflammatory and antipruritic activities. Upon administration of the fluocinonide cream to the affected area(s), fluocinonide binds to the cytosolic glucocorticoid receptor, followed by translocation of the ligand-receptor complex to the nucleus and transcription activation of genes containing glucocorticoid-responsive elements (GREs), which increases the expression of specific target genes, such as lipocortin-1 (annexin A1). The induction of lipocortin-1 expression by fluocinonide leads to an increased interaction and inhibition of cytosolic phospholipase 2 alpha, thereby preventing phospholipase translocation to the perinuclear membrane and subsequent release and conversion of arachidonic acid to inflammatory prostaglandins and leukotrienes. This may relieve symptoms associated with skin inflammation.",
  "synonyms": [
    "fluocinonide"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/fluocinonide-cream/"
}