cPLA2 Inhibiting silicone-based gel AVX001

{
  "id": "MLC-T-ONC-012794",
  "term": "cPLA2 Inhibiting silicone-based gel AVX001",
  "field": "Oncology and biomedicine",
  "definition": "A topical preparation composed of a silicone gel containing a docosahexaenoic acid derivative and cytosolic group IVA phospholipase A2 alpha (cytosolic phospholipase A2 group IVA; cPLA2a; GIVA cPLA2; Group IVA cPLA2) inhibitor, with potential anti-inflammatory activity. Upon topical application to the affected site(s), the cPLA2 inhibiting silicone-based gel AVX001 binds to and inhibits the activity of cPLA2alpha. This may inhibit cPLA2alpha-mediated inflammation. cPLA2alpha catalyzes the release of arachidonic acid from glycerophospholipids and plays a key role in various inflammatory diseases. It is overexpressed in certain cancer cells and may play a key role in proliferation, migration, and chemo-resistance.",
  "synonyms": [
    "silicone-based Gel AVX001"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/cpla2-inhibiting-silicone-based-gel-avx001/"
}