G protein-coupled estrogen receptor agonist LNS8801

{
  "id": "MLC-T-ONC-013799",
  "term": "G protein-coupled estrogen receptor agonist LNS8801",
  "field": "Oncology and biomedicine",
  "definition": "An orally bioavailable selective agonist of the G protein-coupled estrogen receptor (G protein-coupled estrogen receptor 1; GPER; GPER1; GPR30), with potential immunomodulating and antineoplastic activities. Upon oral administration, LNS8801 targets, binds to and activates GPER. This activates GPER-mediated signaling and suppresses the expression of various tumor-associated genes, such as c-Myc and programmed cell death-ligand 1 (PD-L1). This leads to an inhibition of tumor cell proliferation. GPER activation may also induce immune memory. GPER is a membrane protein and a member of the G-protein coupled receptors (GPCRs) that are widely distributed in various tissues. GPER is a tumor suppressor in a wide range of cell cancer types.",
  "synonyms": [
    "GPER agonist LNS8801"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/g-protein-coupled-estrogen-receptor-agonist-lns8801/"
}