Gemcitabine hydrochloride

{
  "id": "MLC-T-ONC-003457",
  "term": "Gemcitabine hydrochloride",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A drug used alone or with other drugs to treat certain types of breast, non-small cell lung, ovarian, and pancreatic cancers that are advanced or have spread to other parts of the body. It is also being studied in the treatment of other types of cancer. Gemcitabine hydrochloride stops cells from making DNA and may kill cancer cells. It is a type of antimetabolite. Gemcitabine is the active ingredient of gemcitabine hydrochloride. Also called Gemzar and Infugem.",
    "The hydrochloride salt of an analogue of the antimetabolite nucleoside deoxycytidine with antineoplastic activity. Gemcitabine is converted intracellularly to the active metabolites difluorodeoxycytidine di- and triphosphate (dFdCDP, dFdCTP). dFdCDP inhibits ribonucleotide reductase, thereby decreasing the deoxynucleotide pool available for DNA synthesis; dFdCTP is incorporated into DNA, resulting in DNA strand termination and apoptosis."
  ],
  "abbreviation": "dFdCyd",
  "synonyms": [
    "Gemzar",
    "Infugem",
    "difluorodeoxycytidine hydrochloride",
    "gemcitabine HCI"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/gemcitabine-hydrochloride/"
}