genistein

{
  "id": "MLC-T-ONC-003497",
  "term": "genistein",
  "field": "Oncology and biomedicine",
  "definitions": [
    "An isoflavone found in soy products. Soy isoflavones are being studied to see if they help prevent cancer.",
    "A soy-derived isoflavone and phytoestrogen with antineoplastic activity. Genistein binds to and inhibits protein-tyrosine kinase, thereby disrupting signal transduction and inducing cell differentiation. This agent also inhibits topoisomerase-II, leading to DNA fragmentation and apoptosis, and induces G2/M cell cycle arrest. Genistein exhibits antioxidant, antiangiogenic, and immunosuppressive activities."
  ],
  "synonyms": [
    "CI 75610",
    "genisteol",
    "genisterin",
    "prunetol",
    "sophoricol",
    "Genestein"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/genistein/"
}