Hpk1 inhibitor PF-07265028

{
  "id": "MLC-T-ONC-014171",
  "term": "Hpk1 inhibitor PF-07265028",
  "field": "Oncology and biomedicine",
  "definition": "An orally bioavailable inhibitor of the serine/threonine enzyme hematopoietic progenitor kinase 1 (Hpk1; Hpk-1; mitogen-activated protein kinase kinase kinase kinase 1; MAP4K1; MEKKK1), with potential immunostimulating and antineoplastic activities. Upon oral administration, Hpk1 inhibitor PF-07265028 targets, binds to and inhibits the activity of Hpk1. This inhibits Hpk1-mediated signaling pathways and prevents Hpk1-mediated immunosuppression by preventing the inhibition of T-cell receptors (TCR) signaling and effector T cells, disrupting abnormal cytokine expression, and abrogating the immunosuppressive tumor microenvironment (TME). This may activate a cytotoxic T-lymphocyte (CTL)-mediated immune response against tumor cells. Hpk1, expressed in hematopoietic cells, is a negative regulator of TCR signaling and T- and B-cell activation.",
  "synonyms": [
    "hematopoietic progenitor kinase 1 inhibitor PF-07265028"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/hpk1-inhibitor-pf-07265028/"
}