human MHC non-restricted cytotoxic T-cell line TALL-104

{
  "id": "MLC-T-ONC-014244",
  "term": "human MHC non-restricted cytotoxic T-cell line TALL-104",
  "field": "Oncology and biomedicine",
  "definition": "An allogeneic human cytotoxic T-lymphocyte cell line with potential antineoplastic activity. Human MHC non-restricted cytotoxic T-cell line TALL-104 is an IL-2-dependent human leukemic T cell line, expressing CD8 and CD3 but not CD16. Upon administration, human MHC non-restricted cytotoxic T-cell line TALL-104 interacts with tumor cells and activates apoptotic and necrotic pathways, resulting in tumor cell lysis. Endowed with MHC-non-restricted killer activity, these cells are cytotoxic against a broad range of tumor cells, sparing normal cells. In addition, TALL-104 may induce secretion of various cytokines, such as interferon-gamma, potentially enhancing its cytotoxic activity.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/human-mhc-non-restricted-cytotoxic-t-cell-line-tall-104/"
}