leflunomide

{
  "id": "MLC-T-ONC-004768",
  "term": "leflunomide",
  "field": "Oncology and biomedicine",
  "definitions": [
    "An anticancer drug that works by inhibiting a cancer cell growth factor. Also called SU101.",
    "A derivative of isoxazole used for its immunosuppressive and anti-inflammatory properties. As a prodrug, leflunomide is converted to an active metabolite, A77 1726, which blocks dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis, thereby preventing the expansion of activated T lymphocytes. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC), thereby inhibiting cell proliferation."
  ],
  "synonyms": [
    "SU101"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/leflunomide/"
}