letrozole

{
  "id": "MLC-T-ONC-004790",
  "term": "letrozole",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A drug used to treat certain types of breast cancer in postmenopausal women. It is also being studied in the treatment of other types of cancer. Letrozole lowers the amount of estrogen made by the body. This may stop the growth of cancer cells that need estrogen to grow. Letrozole is a type of aromatase inhibitor. Also called Femara.",
    "A nonsteroidal inhibitor of estrogen synthesis with antineoplastic activity. As a third-generation aromatase inhibitor, letrozole selectively and reversibly inhibits aromatase, which may result in growth inhibition of estrogen-dependent breast cancer cells. Aromatase, a cytochrome P-450 enzyme localized to the endoplasmic reticulum of the cell and found in many tissues including those of the premenopausal ovary, liver, and breast, catalyzes the aromatization of androstenedione and testosterone into estrone and estradiol, the final step in estrogen biosynthesis."
  ],
  "synonyms": [
    "Femara"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/letrozole/"
}