Levoleucovorin calcium

{
  "id": "MLC-T-ONC-004809",
  "term": "Levoleucovorin calcium",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A drug used to lessen the toxic effects of the anticancer drug methotrexate or other substances that block the action of folic acid. It is also used with fluorouracil as palliative therapy to treat advanced colorectal cancer. Levoleucovorin calcium is a form of folic acid. It is a type of chemoprotective agent and a type of chemosensitizing agent. Also called Fusilev.",
    "A levo isoform of leucovorin calcium with antineoplastic activity. Levoleucovorin is an active metabolite of folic acid, which does not require metabolism by dihydrofolate reductase. This agent counteracts the toxic effects of other folic acid derivative agents, rescuing the patient while permitting the antitumor activity of the folate antagonist. This agent also potentiates the effects of fluorouracil and its derivatives by stabilizing the binding of the drug's metabolite to its target enzyme, thus prolonging drug activity."
  ],
  "synonyms": [
    "Fusilev",
    "calcium levoleucovorin"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/levoleucovorin-calcium/"
}