ligand directed degrader BMS-986460

{
  "id": "MLC-T-ONC-014781",
  "term": "ligand directed degrader BMS-986460",
  "field": "Oncology and biomedicine",
  "definition": "A ligand directed degrader (LDD) composed of an E3 ubiquitin ligase-binding moiety that is conjugated, via a linker, to an as of yet undisclosed moiety that targets a prostate specific tumor-associated antigen (TAA), with potential antineoplastic activity. Upon administration, LDD BMS-986460 specifically and simultaneously targets and binds to the TAA on prostate tumor cells and to E3 ubiquitin ligase, thereby creating a ternary complex. This induces E3 ligase ubiquitination and proteasome-mediated degradation of the TAA. This prevents TAA-mediated signaling and leads to an inhibition of the growth of tumor cells that overexpress the unidentified TAA.",
  "synonyms": [
    "LDD BMS-986460",
    "ligand-directed degrader BMS-986460"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/ligand-directed-degrader-bms-986460/"
}