lipid nanoparticle encapsulated MYC-targeting mRNA-based agent OTX-2002

{
  "id": "MLC-T-ONC-014800",
  "term": "lipid nanoparticle encapsulated MYC-targeting mRNA-based agent OTX-2002",
  "field": "Oncology and biomedicine",
  "definition": "A lipid nanoparticle (LNP)-based formulation consisting of a biscistronic mRNA that encodes two independent epigenomic controllers targeting the proto-oncogene MYC (c-Myc), with potential antineoplastic activity. Upon administration of LNP encapsulated MYC-targeting mRNA-based agent OTX-2002, the lipid formulation promotes the uptake by tumor cells. The biscistronic mRNA is then translated by the cellular protein translation machinery to produce two independent epigenomic controllers consisting of a DNA binding domain and an epigenetic effector protein. The two epigenomic controllers bind to regulatory regions on the MYC insulated genomic domain (IGD), a DNA loop bound by CTCF (CCCTC-binding factor). This downregulates MYC expression pre-transcriptionally, which may inhibit proliferation in susceptible tumor cells. MYC, a proto-oncogene overexpressed in a variety of cancers, plays a role in the regulation of transcription and cell proliferation.",
  "synonyms": [
    "LNP encapsulated MYC-targeting mRNA-based agent OTX-2002"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/lipid-nanoparticle-encapsulated-myc-targeting-mrna-based-agent-otx-2002/"
}