long PD-L1 peptide vaccine

{
  "id": "MLC-T-ONC-014880",
  "term": "long PD-L1 peptide vaccine",
  "field": "Oncology and biomedicine",
  "definition": "A peptide cancer vaccine composed of a long peptide, containing amino acids 19 through 27 (FMTYWHLLNAFTVTVPKDL), obtained from the tumor-associated antigen (TAA) and immune checkpoint molecule programmed cell death-1 ligand 1 (PD-L1), with potential immunomodulating and antineoplastic activities. Upon vaccination with long PD-L1 peptide vaccine, the peptide may activate the immune system to induce an immune response against PD-L1-expressing cells. This may induce a cytotoxic T-lymphocytes (CTLs)-mediated immune response against PD-L1-expressing tumor cells. PD-L1 is overexpressed on many human cancer cell types as well as on antigen presenting cells (APCs) and immunosuppressive cells in the tumor micro-environment (TME), such as regulatory T cells (Tregs). PD-L1 binding to its cognate receptor programmed cell death protein 1 (PD-1; PDCD1; CD279) on T cells suppresses the immune system and results in increased immune evasion and decreased CTL activation.",
  "synonyms": [
    "PD-L1 long(19-27) peptide vaccine",
    "PD-L1 long vaccine"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/long-pd-l1-peptide-vaccine/"
}