LSD1 inhibitor GSK2879552

{
  "id": "MLC-T-ONC-014891",
  "term": "LSD1 inhibitor GSK2879552",
  "field": "Oncology and biomedicine",
  "definition": "An orally available, irreversible, inhibitor of lysine specific demethylase 1 (LSD1), with potential antineoplastic activity. Upon administration, GSK2879552 binds to and inhibits LSD1, a demethylase that suppresses the expression of target genes by converting the dimethylated form of lysine at position 4 of histone H3 (H3K4) to mono- and unmethylated H3K4. LSD1 inhibition enhances H3K4 methylation and increases the expression of tumor-suppressor genes. This may lead to an inhibition of cell growth in LSD1-overexpressing tumor cells. LSD1, overexpressed in certain tumor cells, plays a key role in tumor cell growth and survival.",
  "synonyms": [
    "lysine specific demethylase 1 inhibitor GSK2879552"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/lsd1-inhibitor-gsk2879552/"
}