lucatumumab

{
  "id": "MLC-T-ONC-014898",
  "term": "lucatumumab",
  "field": "Oncology and biomedicine",
  "definition": "A monoclonal antibody directed against the B-cell surface antigen CD40 with potential antineoplastic activity. Lucatumumab binds to and inhibits CD40, thereby inhibiting CD40 ligand-induced cell proliferation and triggering cell lysis via antibody-dependent cellular cytotoxicity (ADCC) in cells overexpressing CD40. CD40, an integral membrane protein found on the surface of B lymphocytes, is a member of the tumor necrosis factor receptor superfamily and is highly expressed in a number of B-cell malignancies.",
  "abbreviation": "MOAB CHIR-12.12",
  "synonyms": [
    "monoclonal antibody CHIR-12.12"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/lucatumumab/"
}