MEK inhibitor SHR 7390

{
  "id": "MLC-T-ONC-015067",
  "term": "MEK inhibitor SHR 7390",
  "field": "Oncology and biomedicine",
  "definition": "An orally available small molecule inhibitor of mitogen-activated protein kinase kinase (MAP2K; MAPK/ERK kinase; MEK), with potential antineoplastic activity. Upon administration, MEK inhibitor SHR 7390 selectively binds to and inhibits the activity of MEK. This prevents the activation of MEK-dependent effector proteins, which results in the inhibition of growth factor-mediated cell signaling and tumor cell proliferation. MEK, a dual-specificity threonine/tyrosine kinase family that plays a key role in the activation of the RAS/RAF/MEK/ERK signaling pathway, is frequently upregulated in a variety of tumor cell types.",
  "synonyms": [
    "MAPK kinase inhibitor SHR 7390",
    "MAP2K inhibitor SHR 7390",
    "MEKi SHR 7390"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/mek-inhibitor-shr-7390/"
}