microbiome-derived peptide vaccine EO2401

{
  "id": "MLC-T-ONC-015165",
  "term": "microbiome-derived peptide vaccine EO2401",
  "field": "Oncology and biomedicine",
  "definition": "A donor-derived, off-the-shelf, microbiome therapeutic cancer peptide vaccine composed of three bacterial onco-mimics, immunogenic microbiome-derived peptides that are highly homologous to tumor-associated antigens (TAAs), that are obtained and selected from the human gut microbiome and are specific for brain tumors, including glioblastoma, with potential immunomodulating and antineoplastic activities. The three microbiome-derived bacterial antigens in EO2401 mimic three TAAs that are highly expressed by brain tumors. Upon administration of microbiome-derived peptide vaccine EO2401, the peptides are taken up by and presented on dendritic cells (DCs) to T cells. As the presented antigens display molecular mimicry with selected TAAs on brain cancer cells, a memory T-cell- and cytotoxic T-lymphocyte (CTL)-mediated immune response may be mounted against the TAAs expressed on the brain cancer cells, thereby eradicating the brain cancer cells.",
  "synonyms": [
    "cancer vaccine EO2401",
    "microbiome-derived therapeutic cancer vaccine EO2401",
    "microbial-derived peptide vaccine EO2401"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/microbiome-derived-peptide-vaccine-eo2401/"
}