midazolam hydrochloride

{
  "id": "MLC-T-ONC-005376",
  "term": "midazolam hydrochloride",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A drug used to treat anxiety and tension and to relax muscles. Midazolam hydrochloride is also being studied in the treatment of nausea and vomiting caused by some cancer treatments. It is a type of benzodiazepine. Midazolam is the active ingredient of midazolam hydrochloride. Also called Versed.",
    "The hydrochloride salt of a short-acting benzodiazepine derivative with an imidazole structure and anxiolytic, amnestic, hypnotic, anticonvulsant and sedative properties. Midazolam binds to the benzodiazepine receptor at the gamma-aminobutyric acid (GABA) receptor-chloride ionophore complex in the central nervous system (CNS), resulting in increases in the opening of chloride channels, membrane hyperpolarization, and the inhibitory effect of GABA. This agent may also interfere with the reuptake of GABA, thereby causing accumulation of GABA in the synaptic cleft."
  ],
  "synonyms": [
    "Versed",
    "midazolam"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/midazolam-hydrochloride/"
}