Mirtazapine

{
  "id": "MLC-T-ONC-005402",
  "term": "Mirtazapine",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A drug used to treat depression. Mirtazapine increases the levels of the chemicals serotonin and norepinephrine in the brain, which helps improve mood. It is a type of antidepressant. Also called Remeron.",
    "A synthetic tetracyclic derivative of the piperazino-azepines with antidepressant activity. Although its mechanism of action is unknown, mirtazapine enhances central adrenergic and serotonergic transmission, possibly by acting as an antagonist at central presynaptic alpha 2 adrenergic inhibitory autoreceptors and heteroreceptors. This agent is a potent antagonist of 5-hydroxytryptamine type 2 (5-HT2), 5-HT3, and histamine 1 (H1) receptors, and a moderate anatgonist of peripheral alpha 1 adrenergic and muscarinic receptors."
  ],
  "synonyms": [
    "Remeron"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/mirtazapine/"
}