mTOR kinase inhibitor OSI-027

{
  "id": "MLC-T-ONC-015318",
  "term": "mTOR kinase inhibitor OSI-027",
  "field": "Oncology and biomedicine",
  "definition": "An orally bioavailable mammalian target of rapamycin (mTOR) kinase inhibitor with potential antineoplastic activity. mTOR kinase inhibitor OSI-027 binds to and inhibits both the raptor-mTOR (TOR complex 1 or TORC1) and the rictor-mTOR (TOR complex 2 or TORC2) complexes of mTOR, which may result in tumor cell apoptosis and a decrease in tumor cell proliferation. mTOR is a serine/threonine kinase that is upregulated in some tumors and plays an important role downstream in the PI3K/Akt/mTOR signaling pathway.",
  "synonyms": [
    "mammalian target of rapamycin kinase inhibitor OSI-027"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/mtor-kinase-inhibitor-osi-027/"
}