namodenoson

{
  "id": "MLC-T-ONC-015414",
  "term": "namodenoson",
  "field": "Oncology and biomedicine",
  "definition": "An orally bioavailable, synthetic, highly selective adenosine A3 receptor (A3AR) agonist with potential antineoplastic activity. Namodenoson selectively binds to and activates the cell surface-expressed A3AR, deregulating Wnt and NF-kB signal transduction pathways downstream, which may result in apoptosis of A3AR-expressing tumor cells. A3AR, a G protein-coupled receptor, is highly expressed on the cell surfaces of various solid tumor cell types, including hepatocellular carcinoma (HCC) cells, and plays an important role in cellular proliferation.",
  "abbreviation": "C-Ibza-MU",
  "synonyms": [
    "A3AdR agonist CF102",
    "adenosine receptor A3 agonist CF102"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/namodenoson/"
}