near-infrared imaging agent HS-196

{
  "id": "MLC-T-ONC-015454",
  "term": "near-infrared imaging agent HS-196",
  "field": "Oncology and biomedicine",
  "definition": "An imaging agent containing a human heat shock protein 90 (Hsp90) inhibitor connected by a linker to a near infrared (NIR) fluorescent dye. Upon intravenous administration, HS-196 selectively and competitively binds to Hsp90 in cells. As Hsp90 is upregulated in a variety of tumor cells, the accumulation of the NIR-tethered imaging agent allows for in vivo detection due to enhanced uptake of HS-196. Hsp90 is a molecular chaperone that plays a key role in the conformational maturation, stability and function of oncogenic signaling proteins, such as HER2/ERBB2, AKT, RAF1, BCR-ABL, and mutated p53, as well as many other molecules that are important in cell cycle regulation and/or immune responses.",
  "synonyms": [
    "HSP90 inhibitor-linked NIR probe HS-196",
    "NIR-tethered Hsp90 inhibitor HS-196"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/near-infrared-imaging-agent-hs-196/"
}