Neuroinflammatory inhibitor MW151

{
  "id": "MLC-T-ONC-015494",
  "term": "Neuroinflammatory inhibitor MW151",
  "field": "Oncology and biomedicine",
  "definition": "An orally bioavailable central nervous system (CNS)-penetrant and inhibitor of certain inflammatory mediators, with potential neuroinflammation attenuating and neuroprotective activities. Upon oral administration, MW151 is able to penetrate the blood-brain-barrier (BBB) and inhibits the up-regulation of certain neuroinflammatory responses upon brain injury or caused by certain diseases. MW151 suppresses neuroinflammation-induced glial activation and prevents the production of certain pro-inflammatory cytokines, such as interleukin-1 beta (IL-1b) and tumor necrosis factor alpha (TNFa). By preventing the overproduction of inflammatory cytokines, over-activated neuroinflammatory pathways are attenuated and associative damage is decreased. This may slow down or prevent certain neurodegenerative disease and cognitive impairment. MW151 may also prevent damage to synapses and synaptic plasticity.",
  "synonyms": [
    "anti-neuroinflammatory agent MW151"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/neuroinflammatory-inhibitor-mw151/"
}