nitroxoline

{
  "id": "MLC-T-ONC-015519",
  "term": "nitroxoline",
  "field": "Oncology and biomedicine",
  "definition": "An orally bioavailable quinoline antibiotic, with potential antineoplastic activity. Upon oral administration, nitroxoline may induce apoptosis and inhibit tumor cell proliferation in NF1-null Schwann cells in neurofibromatosis type I through as of yet undisclosed mechanism of actions, other than inhibiting the RAS/mitogen-activated protein kinase (MAPK) pathway, and possibly through modulating mitochondrial function. NF1 encodes neurofibromin which inactivates Ras. Loss of neurofibromin in neurofibromatosis type I results in increased Ras activity, which promotes the transcription of genes that drives tumor cell growth and proliferation. As an antibiotic, nitroxoline inhibits bacterial RNA polymerase.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/nitroxoline/"
}