nonsense variant

{
  "id": "MLC-T-ONC-005919",
  "term": "nonsense variant",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A change in the DNA sequence of a gene that signals the cell to stop making the protein before it is complete. This results in a shorter protein that may not function. Also called nonsense mutation.",
    "A genetic alteration that causes the premature termination of a protein. The altered protein may be partially or completely inactivated, resulting in a change or loss of protein function. Also called nonsense mutation."
  ],
  "synonyms": [
    "nonsense mutation"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "NCI Dictionary of Genetics Terms"
  ],
  "url": "https://mlchart.com/terminology/oncology/nonsense-variant/"
}